منابع مشابه
Metals, toxicity and oxidative stress.
Metal-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen and nitrogen species, is reviewed. Metal-mediated formation of free radicals causes various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulfhydryl homeostasis. Lipid peroxides, formed by the attack of radicals on polyunsaturated fatty acid residues of p...
متن کاملFolic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol
Folate deficiency and hyperhomocysteinemia are found in most patients with alcoholic liver disease. Oxidative stress is one of the most important mechanisms contributing to homocysteine (Hcy)-induced tissue injury. However it has not been examined whether exogenous administration of folic acid attenuates oxidative stress and hepatic toxicity. The aim of this study was to investigate the in vivo...
متن کاملOxidative Stress and Metal Ion Toxicity
15 16 The thiol-containing tripeptide glutathione is an important cellular constituent of many 17 eukaryotic and prokaryotic cells. In addition to its disulfide reductase activity, 18 glutathione is known to protect cells from many forms of physiological stress. This 19 report represents the first investigation into the role of glutathione in the Gram-positive 20 pathogen, Streptococcus pneumon...
متن کاملDrug-Induced Oxidative Stress and Toxicity
Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that regulate cellular levels of ROS, as their reactive nature may otherwise cause damage to key cellular components including DNA, protein, and lipid. When the cellular antioxidant capacity is exceeded, o...
متن کاملOxidative Stress on Male Reproductive Toxicity
Globally Harmonized System defines Reproductive Toxicity as “an adverse effects (of chemicals) on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring.” Several toxicity assessment studies have been performed taking into account the action of toxicants on reproductive activity. Testis is the main organ of male reproductive system and sperm...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 1992
ISSN: 0378-4274
DOI: 10.1016/0378-4274(92)90086-y